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Menopause, immunosenescence and hormonal balance

With menopause begins the process of immunosenescence (the ageing of the immune system), whereby the immune system’s ability to react starts to diminish, thus increasing the susceptibility to infections, the harmful effects of stress and the risk of autoimmune processes. Changes in the microbiota and sleep patterns are also characteristic of this phase in a woman’s life.

Below you may find the importance of a healthy lifestyle and of micro-immunotherapy as an immunoregulatory treatment to face the often overwhelming changes occurring during and after menopause.

Menopause’s main symptoms

While some women hardly notice any symptoms, others struggle. Each woman experiences menopause differently. However, the most common symptoms are: 

  • Changes in the period
  • Sleep disorders
  • Weight gain
  • Hot flashes
  • Night sweats
  • Reduced sex drive
  • Chest pain
  • Headache
  • Changes in hair colour, texture, and volume
  • Mood swings
  • Tachycardia
  • Water retention

Menopause, Immunosenescence and Micro-immunotherapy

As is known from psychoneuroendocrinoimmunology, the hormonal, the nervous and the immune system are constantly communicating with each other through the hypothalamus-pituitary-adrenal axis (HPA). Thereby, any change in one system will affect the other. 

Interactions between the immune, the nervous and the hormonal systems

In women, the hormonal restructuring that takes place during menopause can lead to an increase in cortisol, the stress hormone. In turn, it is known that the process of immunosenescence (ageing of immunity) entails changes that resemble those observed in chronic stress, including the overactivation of the HPA axis and a proinflammatory, potentially chronic inflammatory state (inflammaging) of the immune system. This comes with an imbalance in glucocorticoids, namely between DHEA (“anti-ageing” hormone with an anti-inflammatory and neuroprotective role) and cortisol, which acts as an immune suppressor. If sustained over time, the conditions associated with inflammaging, including cortisol excess, can be involved in the onset of various diseases such as autoimmune diseases, which are more frequent among women than men. 

During menopause and postmenopause, supporting hormonal balance by regulating the immune system helps prevent the onset of diseases that may result from the process of senescence that goes on as we age. Micro-immunotherapy can be of great help as an immune support during after menopause, promoting healthy ageing as it communicates with the tightly interconnected immune and hormonal systems through low doses of messenger substances, thus equilibrating the factors leading to cellular ageing such as chronic exposure to endogenous glucocorticoids.

Keeping and improving health during menopause

For a healthy menopause, with strong defences, a healthy lifestyle is the best option to minimise the impact of the hormonal fluctuations on immunity and physical and psycho-emotional well-being. 

  1. Balanced diet provides all the macro and micronutrients your body needs (vitamins, minerals and trace elements). 
  2. Avoid sugars, fats, and alcohol and drink sufficient water. 
  3. If you are undergoing stress, it is important to bring in moments of relaxation into your day-to-day life to reduce its harmful effects on the immune system. 
  4. Improve your sleep hygiene
  5. Exercise regularly despite the fatigue
  6. Regulate immunity and support hormonal balance with micro-immunotherapy.

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